Because of the possible similarity of both diseases, the European Society of Cardiology (ESC) recommends timely coronary angiography in patients with suspected myocarditis in order to rule out ACS ( 1, 2).
Patients with acute myocarditis and acute coronary syndrome (ACS) often resemble each other in terms of their clinical presentation and diagnostic findings. Thus, it could support the differential diagnosis between these two disease entities and could facilitate clinical decisions in affected patients. Validation showed good discrimination and calibration of the score.Ĭonclusion: Our clinical score showed good discrimination and calibration for differentiating patients with acute myocarditis and ACS. Logistic regression analysis showed a significant association between total score points and the presence of myocarditis ( B = 0.9078, p 99.9% 92.9% pred. Results: A score for prediction of acute myocarditis was calculated using six parameters. Validation was conducted in a separate cohort of 90 patients. Cutoffs for the prediction of myocarditis were calculated. Logistic regression was conducted using the identified parameters and score points for each level of the predictors were calculated. Least absolute shrinkage and selection operator (LASSO) regression was conducted to identify parameters associated with the highest or least probability for acute myocarditis. Materials and Methods: Patients with ACS ( n = 233) and acute myocarditis ( n = 123) were retrospectively enrolled. The aim of this study was to develop such a score to aid the physician in scenarios where discrimination between myocarditis and ACS appears difficult. To date, no clinical score exists to support the differentiation between these two diseases. 2Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University, Salzburg, Austriaīackground: Acute myocarditis and acute coronary syndrome (ACS) are important differential diagnoses in patients with new-onset chest pain.1Division of Cardiology, Department of Internal Medicine II, Paracelsus Medical University, Salzburg, Austria.Moritz Mirna 1*, Lukas Schmutzler 1, Albert Topf 1, Brigitte Sipos 1, Lukas Hehenwarter 2, Uta C.